色素内镜诊断早期胃癌的临床应用研究

Research on the Clinical Application of Chromoendoscopy in the Diagnosis of Early Gastric Cancer

目的探讨色素内镜对早期胃癌的癌前病变的诊断价值。方法 2010年1月至2011年1月间68例常规胃镜检查下疑为早期胃癌的患者,其中38例予以色素内镜检查,30例予以单纯活检作为对照组,并与手术切除灶的病理结果进行分析比较。结果经黏膜染色后活检有31例病理结果为胃癌,诊断的阳性率为81.6%(31/38),手术后病理结果证实有28例为早期胃癌,诊断的阳性率为73.7%(28/38);对照组诊断胃癌以及早期胃癌的阳性率分别为43.3%(13/30)和23.3%(7/30),两组间比较,差异显著(P<0.05)。结论色素内镜诊断黏膜结构更清晰,对病变的定位以及目的性活检有利,可显著提高活检的阳性率,具很高的临床应用价值。

Objective To explore the diagnosis value of chromoendoscopy in the diagnosis of early gastric cancer.Methods 68 patients suspected early gastric cancer from January 2010 to January 2011 in our hospital were selected in this stusy.38 cases were diagnosed by chromoendoscopy,30 cases were diagnosed by biopsy alone as control group.The results were compared with the pathology results.Results 31 patients were diagnosed as gastric cancer and the positive rate was 81.6%（31/38）.28 patients were diagnosed as early gastric cancer by pathological diagnosis and the positive rate was 73.7%（28/38）.Meanwhile,in control group,the positive rate of gastric cancer and early gastric cancer was 43.3%（13/30） and 23.3%（7/30）,respectively.The differences of diagnostic accuracy between two groups were statistically significant（P 0.05）.Conclusions Diagnosing the mucous membrane by chromoendoscopy is clearer and beneficial for locating pathological changes and teleonomy biopsy.Chromoendoscopy can improve the diagnostic accuracy,which is worthy of clinical generalization and application.