盐酸沙拉沙星在凡纳滨对虾体内的残留消除规律

Residue and elimination regularity of sarafloxacin hydrochloride in Litopenaeus vannamei

在水温为(29.0±1.0)℃、盐度为3.3%条件下,以30mg/kg的剂量单次药饵投喂凡纳滨对虾盐酸沙拉沙星后,分别取凡纳滨对虾血淋巴、肝胰腺和肌肉样品,采用反相高效液相色谱法测定样品中的药物浓度。结果表明:盐酸沙拉沙星在肝胰腺中的药物残留浓度远高于血淋巴和肌肉,后两者的药物残留浓度比较低而且血淋巴中的残留浓度高于肌肉;给药后盐酸沙拉沙星在血淋巴、肝胰腺和肌肉中的消除速率快慢不一,在肌肉中消除速度最快,肝胰腺中的消除速度快于血淋巴。

The shrimp were kept in tanks with recirculated seawater at a salinity of 3.3%. The wa- ter temperature was maintained at （29.01-1.0） ℃. Hemolymph, hepatopancreas and muscle were sam- pled after administration of sarafloxacin hydrochloride at single dose of 30 mg/kg and the residue con- centration of sarafloxacin hydrochloride analyses was performed by RP-HPLC. The results showed that, the residue concentration of sarafloxacin hydrochloride in hepatopancreas was higher than hemolymph and muscle. The residue concentration of hemolymph and muscle were very low and the former is higher than the latter. The elimination rate was markedly different in hemolymph, heparopancreas and muscle. The elimination half-life of sarafloxacin hydrochloride was the shortest in muscle among the three tissues and the longest in hemolymph.