孟鲁司特联合雾化吸入在支气管哮喘中的临床研究

目的:探讨孟鲁司特联合雾化吸入在支气管哮喘中的临床效果。方法:按就诊顺序选取在我院治疗的支气管哮喘患者80例分为联合组和对照组。对照组(37例)使用常规抗生素、激素、茶碱类药物进行治疗;联合组(43例)每日睡前口服孟鲁司特加雾化吸入沙美特罗。对比两组疗效和肺功能改善程度。结果:联合组治疗总有效率为93.0%,临床症状减轻,与对照组的81.1%相比差异显著,有统计学意义,P<0.05。治疗后两组患者的肺功能较治疗前均有改善,联合组第一秒用力呼气容积占预计量百分比(FEV1%)和最大呼气流量占预计值百分比(PEF%)较对照组改善明显,差异有统计学意义,P<0.05。结论:利用孟鲁司特联合雾化吸入的协同作用治疗支气管哮喘的临床疗效显著。

Objective： To explore the clinical effect of Montelukast combined with aerosol inhalation in treatment of bronchial asthma. Methods： Orderly selected 80 cases of bronchial asthma patients treated in our hospital and d：ivided into combined group and control group. The control group （n = 37） were treated by conventional antibiotics, hormones and theolahyUine; combined group （ n = 43） were treated by Montelukast plus aerosol inhalation of Salmeterol before bedtime. Compare two groups with clinical efficacy and pulmonary function improvement. Results： Total effective rate of combined group was 93.0%, the clinical symptoms decreased. The differences were statistically insignificant compared with the control group （81.1%）, P 〈0. 05. Lung function of patients were im- proved after treatment than before treatment, FEVI% and PEF% of the combined group were highly improved than the control group, there were statistically significant, P 〈 0. 05. Conclusions： Use the synergistic effect of Montelukast combined aerosol inhalation in treatment of bronchial asthma shows significant clinical effect.