急性脑出血患者血清PAO动态变化及临床意义

The Changes and clinical significance of PAO in the patients with acute cerebral hemorrhage

目的:探讨脑出血患者血清多胺氧化酶(PAO)变化及临床意义。方法:采用酶联免疫吸附试验(ELISA)检测40例急性脑出血患者发病后第1、3、7、14天及40例健康对照者血清PAO水平,分析急性脑出血PAO动态变化与神经系统功能缺损程度评分(CSS)和预后的关系;并于发病第1、3天进行头颅CT检查,计算脑水肿面积及出血量。结果:①急性脑出血组各时间点血清PAO水平均高于对照组(均P<0.05),并随着发病时间的延长,血清PAO水平逐渐下降(均P<0.05);②发病第1d和第3d患者血清PAO水平随着脑出血体积的增加而显著增加(P<0.05);③急性脑出血患者入院第1d、第3d、第7d、第14d神经缺损功能CSS评分和血清PAO水平呈正相关(均P<0.05)。结论:急性脑出血患者血清PAO水平明显增高,可作为判断脑出血量和病情预后的血液指标。

Objective： To explore the Changes and clinical significance of polyamine oxidase （PAO） in the patients with acute cerebral hemorrhage. Methods： 40 patients with acute cerebral hemorrhage （ACH group） and 40 healthy volunteers （ Control group） were recruited from zhacqing first people＇ s hospital. The serum levels of PAO in patients with ACH at the 1st day, 3rd day, 7th day, and 14th day were detected by enzyme -linked immunisorbent assay （ELISA） . The status of all patients were evaluated by CSS at the corresponding time points. The volume of cerebral hemorrhage were calculated by CT at the 1st day and 3rd day. Results： ①The ser- um levels of PAO in ACH group were higher than the control group （P 〈0. 05） ; ②The serum levels of PAO increased wih the volume of cerebral hemorrhage at the 1st day and 3rd day （P 〈0. 05） ; ③The serum levels of PAO correlated significantly with CSS at the corresponding time points. Conclusions： The serum levels of PAO increase after ACH, which may be a valuable index for the cerebral hemorrhage volume and prognosis.