地佐辛用于全麻诱导的舒适度研究

STUDY ON COMFORTABLE DEGREE OF INDUCTION OF ANESTHESIA WITH DEZOCINE AS INDUCTION AGENT

目的对比研究地佐辛与芬太尼用于全麻诱导对病人舒适度的影响。方法 120例ASAⅠ～Ⅱ级择期手术全麻患者,随机分为D组和F组,每组60例。D组静脉注射0.2 mg.kg-1地佐辛进行麻醉诱导,F组则静脉给予3μg.kg-1芬太尼进行麻醉诱导。观察并记录诱导时丙泊酚的注射痛评分及发生率,插管前呛咳程度及发生率,拔管即刻(T1)、拔管后5 min(T2)的躁动评分,拔管后呕吐发生情况,术后4、8、12小时的VAS评分值,及术后24小时的满意度评分。结果 D组丙泊酚的注射痛评分及发生率,插管前呛咳程度及发生率,拔管即刻(T1)、拔管后5 min(T2)的躁动评分,拔管后恶心呕吐发生率,术后4、8、12小时的VAS评分均低于F组,差异均有统计学意义(p<0.05);D组术后24小时的满意度评分高于F组,差异有统计学意义(p<0.05)。结论地佐辛用于全麻诱导可提高患者的舒适度。

Objective To compare the effect of Dezocine and fentanyl for anesthesia induction on the comfortable degree. Methods 120 patients with ASA standard I - II scheduled for surgery on general anesthesia with tracheal intubation were randomly divided into the D group and the F group with 60 cases in each. The patients in the D group were administrated with Dezocine 0. 2 mgokg- 1 intravenously, while-the patients in the F group were adminis- trated with fentanyl 3 μgokg - 1 intravenously to anesthesia induction. The incidences and scores of pain associated with IV injection of propofol, the incidences and severity of coughing before intubation,the agitation scores at extuba- tion （ T1 ） and 5 min after extubation （T2） , the incidences of nausea and vomit after extubation, the scores of VAS and the scores of anesthesia satisfactions at 24 hours after the operation were observed and recorded. Results All were lower with the incidences and scores of pain associated with IV injection of propofol, the incidences and severity of coughing before intubation, the agitation scores at extubation （ T1 ） and 5 min after extubation （ T2 ）, the incidences of nausea and vomit after extubation, the scores of VAS at 4,8,12 hours after the operation in D group than those in F group, there were of statistical differences between the two groups （p 〈 0. 05 ）. This was higher with the score of anesthesia satisfactions at 24 hours after the operation in D group than that in F group, there were of statistical differences between the two groups （p 〈 0. 05 ）. Conclusion Dezocine for anesthesia induction could improve the comfort- able degree of patients under general anesthesia with tracheal intubation.