心力衰竭患者血浆氨基末端脑钠肽前体的测定与护理干预

Plasma N-terminal pro-brain natriuretic peptide determination in chronic heart failure patients and their nursing intervention

目的了解心力衰竭（CHF）患者血浆N端脑钠肽前体（NT—proBNP）的水平及探讨护理干预对慢性CHF患者的影响。方法测定150例CHF患者和140例正常组血清NT—proBNP水平；将150例慢性CHF患者随机分成干预组和对照组，对照组给予住院期间常规药物治疗及护理，干预组在此基础上进行护理干预。采用明尼苏达生活质量量表（MHL评分）评价两组病人干预前后生活质量的改变。结果CHF患者血中M-pr0BNP水平明显高于对照组（P〈0．01），两组cHF患者在护理干预前生活质量无明显差异（P〉0．05），护理干预后两组患者生活质量有明显差异（P〈0．05）.结论血浆NT—proBNP水平对于早期判断心功能不全的程度有参考意义，实施护理干预可以提高CHF患者的生活质量。

Objective To understand the plasma of patients with N terminal pro brain natriuretic peptide （ NT-proBNP ） level in patients with chronic heart failure （CHF） and explore the effect on nursing intervention on these patients. Methods The serum NT-proBNP level 150 patients with CHF and 140 cases of control group were determined. The 150 CHF patients were randomly divided into intervention group and control group. Control group was given routine treatment and nursing care during hospitalization. Basing on control group＇s treatment, intervention group were given nursing intervention. The Minnesota quality of life scale （ MHL score） was used to evaluate the life quality of all patients in both groups before and after treatment. Results The blood NT-proBNP was significantly higher in intervention group than in control group （ P 〈 0.01） after treatment. Before treatment, there was no difference in life quality between the two groups. However, after treatment, life quality was significantly better in intervention group than in control group. Conclusions Plasma NT- proBNP has reference significance for the early determination of the severity of heart failure. Nursing intervention can improve CHF patients＇ life quality.