BED发病捕获酶联法检测宁夏男男性行为人群HIV新发感染

Estimation of HIV incidence of MSM with BED incidence capture enzyme immunoassay in Ningxia

目的了解宁夏2011年哨点男男性行为人群(MSM)艾滋病病毒(HIV)新发感染情况,计算新发感染率。方法收集哨点监测人群男男性行为400例,应用BED HIV-1发病捕获酶免疫测定法(BED-CEIA)对HIV-1阳性的样本进行新发感染检测,计算新发感染率。结果 HIV-1感染率为3.75%,感染者中新发感染的比例为33.33%,新发感染率为2.48%(95%CI:0.31%～4.66%)。结论 BED-CEIA方法可应用于哨点男男性行为人群及其他人群,对其新近感染率的计算和估计具有实用性,对艾滋病防治政策的制定和调整具有参考作用。

Objective To understand HIV infection of men who have sex with men （MSMs } in Ningxia, and estimate the an- num HIV incidence of MSMs. Methods 400 samples from national pilot work of HIV/AIDS compreilensive prevention and care among MSMs in 2011 were tested to find HIV - 1 seropositive samples. BED HIV - 1 IgG capture enzyme Jmmunoassay （ BED - CEIA） was used to find recent HIV - 1 infections in HIV - 1 seropositive samples and the annual HIV - 1 incidence of MSMs was estimated. Results The HIV - 1 infection incidence was 3.75%, and the recent infection rate was 33.33% in the men who had been tested the HIV. The corrected annual HIV - 1 incidence was 2.48% （95% CI： 0.31% -4.66% ） among MSlVls. Conclusion BED - CEIA is an appropriate approach to be used in sentinel MSM population and other populations, and it offers valuable information for the develop- ment of HIV/AIDS control strategy by estimating recent infections and controlling potential deviations.