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舒芬太尼复合氟比洛芬酯在老年患者全髋置换术后静脉自控镇痛中的应用 被引量:8

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摘要 目的观察舒芬太尼复合氟比洛芬酯在老年全髋置换患者术后静脉自控镇痛中的效果。方法将择期行全髋置换术患者60例随机分为A、B、C 3组,每组20例。A组术后静脉自控镇痛采用舒芬太尼150μg+阿扎司琼10 mg+0.9%氯化钠稀释至100 mL(舒芬太尼1.5μg.mL-1);B组采用氟比洛芬酯150 mg+舒芬太尼100μg+阿扎司琼10 mg+0.9%氯化钠稀释至100 mL(舒芬太尼1μg.mL-1+氟比洛芬酯1.5 mg.mL-1);C组采用氟比洛芬酯150 mg+舒芬太尼150μg+阿扎司琼10 mg+0.9%氯化钠稀释至100 mL(舒芬太尼1.5μg.mL-1+氟比洛芬酯1.5 mg.mL-1)。观察并记录患者术后6 h(T1)、12 h(T2)、24 h(T3)、48 h(T4)疼痛、镇静评分以及术后24 h内PCIA泵按压次数。结果与A组比较,B组和C组T2、T3、T4时疼痛评分降低(P<0.05),24 h内PCIA泵按压次数明显减少(P<0.05),B组T1、T2、T3时镇静评分明显降低(P<0.05);与C组比较,B组T1、T2、T3时镇静评分降低(P<0.05)。结论舒芬太尼1μg.mL-1+氟比洛芬酯1.5 mg.mL-1可为老年全髋置换患者提供良好的镇痛效果,不良反应发生少。
出处 《实用临床医学(江西)》 CAS 2012年第5期45-46,共2页 Practical Clinical Medicine
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  • 1Ohmukai O.Lipo -NSAID preparation.Advanced Drug Delivery Reviews,1996,20:203 ~ 207.
  • 2Swift JQ,Garry MG,Roszkowski MT,et al.Effect of flurbiprofen on tissue levels of immunoreactive bradykinin and acute postoperative pain.J Oral Maxillofac Surg,1993,51:112 ~ 116.
  • 3Perttunen K,Nilsson E,Kalso E.Iv diclofenac and ketorolac for pain after thoracoscopic surgery.Br J Anaesth,1999,82:221 ~ 227.
  • 4Tarkkila P,Saarnivaara L.Ketoprofen,diclofenac or ketorolac for pain after tonsillectomy in adults? Br J Anaesth,1999,82:56 ~ 60.
  • 5Wei Wupang,Car J Anesth,1999年,46卷,1030页
  • 6Ohmukai O.Lipo-NSAID preparation.Adu Drug Delivery Rev,1996,20:203-220.
  • 7Dahl JB,Moiniche S.Pre-emptive analgesia.Br Med Bull,2004,71:13-27.
  • 8Bannwarth B,Demotes-Mainard F,Schaeverbeke T,et al.Centralanalgesic effects of aspirin-like drugs.Fundam Clin Pharmacol,1995,9:1-7.
  • 9Joris J.Efficacy of nonsteroidal antinflammatory drugs in postoperative pain.Acta Anaesthesiol Belg,1996,47:115-123.
  • 10Ochroch EA,Mardini IA,Gottschalk A.What is the role of NSAIDs in pre-emptive analgesia? Drugs,2003,63:2709-2723.

共引文献179

同被引文献56

  • 1王平,王为民,张君涛.膝OA关节镜术后疼痛原因分析[J].中国骨伤,2004,17(7):414-415. 被引量:14
  • 2段砺瑕,李晓玲.氟比洛芬酯注射液的药理作用及临床应用[J].中国新药杂志,2004,13(9):851-852. 被引量:601
  • 3鲁小民,胡志强,蒋民霞.皮下自控镇痛(PCSA)与静脉自控镇痛(PCIA)的临床比较[J].实用临床医学(江西),2006,7(10):96-97. 被引量:8
  • 4Bernard Schachtel,Sue Aspley,Adrian Shephard,Timothy Shea,Gary Smith,Kathleen Sanner,Laurie Savino,Jeanne Rezuke,Emily Schachtel.Onset of action of a lozenge containing flurbiprofen 8.75&lt;ce:hsp sp="0.25"/&gt;mg: A randomized, double-blind, placebo-controlled trial with a new method for measuring onset of analgesic activity[J].Pain.2013
  • 5Estefanía Vega,M. Antònia Egea,M. Luisa Gardu?o-Ramírez,M. Luisa García,Elena Sánchez,Marta Espina,Ana Cristina Calpena.Flurbiprofen PLGA-PEG nanospheres: Role of hydroxy-β-cyclodextrin on ex vivo human skin permeation and in vivo topical anti-inflammatory efficacy[J].Colloids and Surfaces B: Biointerfaces.2013
  • 6Sujash Halder,Kanchan Mondal,Supreeti Biswas,Tapan Mandal,Bakul Dutta,Mithilesh Haldar.Comparative evaluation of aqueous and plasma concentration of topical moxifloxacin alone and with flurbiprofen in patients of cataract surgery[J].Indian Journal of Pharmacology.2013(3)
  • 7Jyun-Fen Ciou, Pei-Yun Wang, An-Chi Wu, et al. Lipasecatalyzedalcoholytic resolution of( R,S)-flurbiprofenyl azolides forpreparation of( R)-NO-flurbiprofen ester prodrugs. Process biochemistry,2011, 46(4): 960-965.
  • 8Mohammad Tariq, Zeenat Iqbal, Javed Ali, et al. Developmentand Validation of a Stability-Indicating High-Performance Thin-LayerChromatographic Method for the Simultaneous Quantification of Sparfloxacinand Flurbiprofen in Nanoparticulate Formulation. Journal of PlanarChromatography-Modern TLC: JPC, 2014, 27(2): 124-131.
  • 9Lucia Tamborini, Diego Romano, Andrea Pinto, et al. An efficientmethod for the lipase-catalysed resolution and in-line purification of racemicflurbiprofen in a continuous-flow reactor. Journal of molecular catalysis, B.Enzymatic, 2012,( 84): 78-82.
  • 10雷钟,刘亚华,段惠洁,吴泰相.经静脉与硬膜外两种自控镇痛方式效果的系统评价[J].中国循证医学杂志,2009,9(8):880-886. 被引量:12

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