肌红蛋白诊断早期心肌梗死的特异性研究

Study on the specificity of myoglobin for the diagnosis of early myocardial infarction

目的 探讨肌红蛋白在早期心肌梗死死后诊断的特异性。方法 应用免疫组织化学S -P法检测梗死心肌和其它非梗死性的直接或间接心肌损害的心肌肌红蛋白染色的变化。结果 梗死心肌均可见不同程度的肌红蛋白缺染 ,其它非梗死性的直接或间接心肌损害的心肌中 ,如心脏挫伤、心肌炎、出血性休克、电击死、机械性窒息、有机磷中毒等 ,也有不同程度的肌红蛋白缺染。

Objective To explore the specificity of myoglobin (Mb) in the postmortem diagnosis of early myocardial infarction Methods The cardiac samples were obtained from forensic autopsy, the changes of Mb staining in the infarcted myocardium and other non infarcted myocardium with direct or indirect myocardial injury were studied with immunohistochemical S P method Results The loss of Mb staining in the infarcted was in different, but similar features was found in the non infarcted myocardium with direct or indirect myocardial injury, such as cardiac contusion, myocarditis, hemorrhagic shock, electrocution,mechanical asphyxia and organophosphate poisoning Conclusion There is no specificity in postmortemdiagnose early myocardial infarction with Mb immunohistochemisrty