乳腺浸润性导管癌bcl-2、bax基因蛋白表达与预后的关系

Expression and prognostic value of bcl-2 and bax gene protein in breast invasive ductal carcinoma

目的 :研究bcl 2、bax基因蛋白在乳腺浸润性导管癌中表达的相关性及和预后的关系。方法 :应用免疫组织化学ABC法检测乳腺浸润性导管癌组织bcl 2、bax基因蛋白的表达。结果 :存活组bcl 2基因蛋白阳性表达率 (46 / 6 5 )明显高于死亡组的bcl 2阳性表达率 (12 / 35 ) ,且bcl 2基因蛋白表达与淋巴结转移和临床分期呈负相关关系 ;而bax在死亡组的阳性率 (31/ 35 )显著高于存活组 (2 6 / 6 5 ) ,与淋巴结转移和临床分期呈正相关关系 ;bcl 2 (+)bax (- )组的存活率 (2 5 / 2 6 )较bcl 2 (- )bax (+)组存活率 (5 / 2 5 )相差有显著性。bcl 2 /bax 1组的存活率 (5 5 / 6 8)较bcl 2 /bax <1组存活率 (10 / 32 )高 ,相差有显著性意义。结论 :bcl 2。

Purpose:To investigate the relationship between the expression of bcl 2,bax gene protein and its relationship with the prognosis of breast invasive ductal carcinoma.Methods:The expression of bcl 2,bax gene protein was detected in breast invasive ductal carcinoma by ABC immunohistochemical staining.Results:The positive expression rate of bcl 2 in the surviving group (70.8%,46/65) was significantly higher than in the dead group (34.3%,12/35). The expression of bcl 2 was inversely related to lymph node metastasis and clinical staging. However,the positive expression rate of bax was significantly higher in the dead group (88.6%,31/35) than in the surviving group (40.0%,26/65). It was positively related to lymph node metastasis and clinical staging. The survival rate of bcl 2(+)bax(-) group was significantly different from the bcl 2(-)bax(+) group. The survival rate in bcl 2/bax1 group (80.9%,55/68) was significantly higher than in bcl 2/bax<1 group (30.3%,10/32).Conclusions:The expression of bcl 2、bax gene protein was of great value in the prediction of prognosis in patients of breast carcinoma.