多发性后极部色素上皮病变的吲哚青绿和荧光素眼底血管造影

Indocyanine green and fluorescein angiographies of multifocal posterior pigment epitheliopathy

目的 研究多发性后极部色素上皮病变 (multifocal posterior pigment epitheliopathy,MPPE)的视网膜和脉络膜循环特点 ,探讨该病的发病机制及其与中心性浆液性脉络膜视网膜病变 (central serouschorioretinopathy,CSC)之间的关系。 方法 对 6例 MPPE患者的 7只眼吲哚青绿血管造影 (indocyaninegreen angiography,ICGA)和荧光素眼底血管造影 (fundus fluorescein angiography,FFA)检查结果进行对比分析。 结果 5例 5只眼 FFA检查为活动期 ,其中 4只眼在 ICGA造影早期有脉络膜充盈延迟 ,占 80 %。FFA显示有渗漏处 ,ICGA均有相应的渗漏灶。在渗漏灶的周围及后极部尚有弥漫性相对强荧光。病变恢复期 ,FFA已无明显渗漏 ,ICGA仍显示脉络膜荧光渗漏。 结论 MPPE与 CSC有着相同的 ICGA改变 ,但前者病变范围更加广泛。 MPPE为 CSC的较严重型 ,为原发于脉络膜病变的疾病。

Objective To observe the findings of indocyanine green angiography(ICGA) and fundus fluorescein angiography (FFA) of the patients with multifocal posterior pigment epitheliopathy(MPPE). Methods ICGA and FFA were performed in 6 cases(7 eyes)of MPPE and the findings were analysed and compared between these examinations. Results Five cases(5 eyes)were found to be in the active stage of the disease under FFA,and among them 4 eyes(80%)showed delayed choroidal perfusion at the early stage of ICGA.During the active stage of the disease,ICGA showed leakage relative to FFA leakage,and there were diffuse hyperfluorescence around the points of leakages as well as in the posterior pole of ocular fundus.In convulescence,although FFA revealed no obvious leakage,ICGA still denoted the presence of leakages. Conclusions MPPE was considered to be the more serious type of central serous chorioretinopathy showing the same but more extensive ICGA abnormality.