动态血压和偶测血压与糖尿病视网膜病变的关系

A correlative study on diabetic retinopathy with casual and ambulatory blood pressure

目的 研究血压升高和昼夜节律与糖尿病视网膜病变的关系。方法 以50例健康人为对照,对94例血压正常的非胰岛素依赖型糖尿病患者进行偶测血压、24h动态血压监测。结果 非胰岛素依赖型糖尿病患者的24h、白天、夜间平均舒张压均比对照组明显升高,夜间收缩、舒张压下降百分率均明显降低,昼夜节律消失,与眼底改变呈明显正相关(P<0.01),偶测血压与眼底改变无相关性(P>0.05)。结论 随着血压昼夜节律消失及舒张压持续升高,可能导致视网膜血管病变的发生。动态血压与视网膜病变的相关性要较偶测血压为好。

Objective To find the relation between diabetic retinopathy and blood pressure or circatian rhythm.Method For investigating the changes of casual and ambulatory blood pressure in patients with diabetes mellitus,94 patients with non insulin dependent diabetes mellitus(NIDDM) but with normal blood pressure and 50 normal controls were studied.Results The average 24h diastolic blood pressure(DBP),day time DBP and night time DBP of the NIDDM patients were significantly increased compared with those of the controls,the percentage of reduction in night time systolic blood pressure(SBP) and DBP were significantly decreased and correlated with the change in retinopathy( P <0.01).There was no correlation between casual blood pressure and the fundus changes( P >0.05).Conclusion The disappearance of circadian variation of blood pressure and the increase in night time BP may induce diabetic retinopatly.Ambulatory blood pressure has better correlation with diabetic retinopathy than casual blood pressure.