国产洛美沙星胶囊的人体药物动力学

Pharmacokinetics of orally administered lomefloxacin

目的 :研究健康志愿者单剂口服国产洛美沙星胶囊 40 0mg后的药物动力学特征。方法 :采用HPLC法测定血清和尿中药物浓度。结果 :该药在人体内的转运过程符合二室开放模型 ,血药峰浓度为 4.88mg·L-1,消除半衰期为 7.19h ,表观分布容积和AUC分别为 1.5 1L·kg-1和 5 1.0 3h·mg·L-1,总清除率为 2 .47ml·min-1·kg-1,48h尿药排泄率为 75 .7%。洛美沙星的人血清蛋白结合率为 16 .3%。结论 :本研究提示洛美沙星 40

OBJECTIVE:The pharmacokinetics of lomefloxacin were determined after a single 400 mg oral dose given to eight male volunteers.METHODS:Concentrations in serum and urine were determined by high performance liquid chromatography(HPLC).RESULTS:Lomefloxacin concentration time profile comformed to an open two compartment model.The mean serum peak level was 4.88 mg·L -1 .The mean serum elimination half life was 7.19 h.The apparet volume of distrabution and AUC were 1.51 L·kg -1 and 51.03 h·mg·L -1 ,respectively.The total body clearan averaged 2.47 ml·min -1 ·kg -1 .The mean recovery of lomefloxacin from urin over 48 h was 75.7% .About 16.3% lomefloxacin was protein bound in serum.CONCLUSIONS:Concentrations of lomefloxacin in serum and urine were high.The serum elimination half life was long.