美洛昔康片溶出度测定方法的研究

Study on test method of dissolution for meloxicam tablets

目的 :建立美洛昔康片溶出度测定法 ,并纳入药品标准。方法 :选用中国药典 1995年版溶出度测定法第二法 ,紫外分光光度法检测。结果 :测定波长为 2 73nm ,浓度在 5～ 2 5 μg·ml-1范围内 ,与吸收度呈良好的线性关系 (r =0 .9999) ,平均回收率为 10 0 .2 % ,RSD为 0 .3% (n =6 ) ,每片溶出量应为标示量的 80 %以上。结论

OBJECTIVE:To develop a method of dissolution test for meloxicam tablets.METHODS:Dissolution method Ⅱ of the Chinese Pharmacopoeia 1995 was used,UV spectrophotometry was adopted for the determination.RESULTS:Detection wave length was 273 nm,the average recovery was 100.2% ( n =6, RSD = 0.3% ),it had good linearity in the concentration range of 5～25 μg·ml -1 , r = 0.999 9 ,the percentage of dissolution of meloxicam in 30 min were more than 80%.CONCLUSIONS:This method could be applied to the determination of dissolution of meloxicam tablets.