酪酸梭菌活菌片对常用抗菌药物的体外敏感性检测

Detection of in Vitro Susceptibility to Commonly Used Antimicrobial Agents in Clostridium Butyricum Tablets

目的检测酪酸梭菌活菌片中活性酪酸梭菌对常见抗菌药物的体外敏感性。方法选取15种常见抗菌药物,通过纸片法进行体外抗菌药物敏感性试验。结果酪酸梭菌种对头孢噻肟、头孢唑林、氨基苷类、磺胺类抗菌药物表现为耐药;对青霉素、大环内酯类、喹诺酮类药物敏感。结论酪酸梭菌可与头孢菌素、氨基苷类、磺胺类等抗菌药物联用,应避免与青霉素类、大环内酯类、喹诺酮类药物联用。

Objective To detect the in vitro susceptibility of active clostridium butyricum to antimicrobial agents in Clostridium Butyricum Tablets. Methods The bacterial inhibition zone method was adopted to perform the in vitro susceptibility test to 15 kinds of common antibacterial drugs. Results Clostridium Butyricum showed resistant to cefotaxine, cefazolin,aminoglycosides and sulfonamides and sensitive to penieillin,macrolides and quinolones. Conclusion Clostridium Butyricumcan can be used in combination use with cefotaxine, cefazolin, aminoglycosides and sulfonamides,but should be avoided the combination use with penicillin,macrolides and quinolones.