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血管紧张素Ⅱ及其转化酶抑制剂与慢性胰腺炎的研究进展 被引量:1

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摘要 慢性胰腺炎的病理特征是胰腺纤维化,其主要的效应分子血管紧张素Ⅱ(AngⅡ)可促进细胞增殖和纤维化的形成。通过研究血管紧张素Ⅱ在胰腺星状细胞、ECM、TGF-β1中的作用,使用血管紧张素转化酶抑制剂(ACEI)或受体拮抗剂可减轻胰腺纤维化程度,奠定了血管紧张素Ⅱ转化酶抑制剂在胰腺纤维化防治上的基础。
作者 张林洁
出处 《中国药业》 CAS 2012年第14期111-112,共2页 China Pharmaceuticals
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