动态血糖监测结合胰岛素泵强化治疗2型糖尿病的疗效观察

Investigate the Superiority of Insulin Pumps on the Treatment of Diabetes Mellitus by Continuous Glucose Monitoring System

目的用动态血糖监测系统(CGMS)比较动态血糖监测与指血血糖监测分别结合胰岛素泵持续皮下胰岛素注射(CSII)强化治疗2型糖尿病的疗效。方法将40例糖尿病患者随机分为双C组(20例)及对照组(20例)。以CGMS观察治疗2周后血糖谱的变化,比较两种治疗方法在全天平均血糖、血糖≤3.9mmol/L时间百分比〔TPG≤3.9mmol/L(%)〕、血糖≥10mmol/L时间百分比〔TPG≥10mmol/L(%)〕控制血糖水平。结果双C组血糖控制效果明显优于对照组(P<0.05)。结论 CGMS结合CSII强化治疗糖尿病疗效明显优于对照组。

Objective To investigate the superiority of insulin pumps on the treatment of diabetes mellitus （DM） by continuous glucose monitoring system （CGMS）. Methods 40 DM patients were divided into CSII and multiple subcutaneous in- sulin injection （MSII） groups randomly. CSII group had 20 cases which were given insulin pumps and MSII had 20 eases which were given MSII methods. The daily blood glucose profiles were observed after treatment for 2 w by CGMS. Results The thera- peutic effect of blood eontreliing in CSII group was superiority to that in MSII group （ P 〈 0. 05 ）, and the incidence of hypoglyee- mia was lower than that in MSII group （P 〈 0. 01 ）. Conclusion Insulin pumps shows less nocturnal hypoglycemia and more stable blood glucose profile with less excursion.