米索前列醇预防产后出血的临床观察

Clinical observation of misoprostol in preventing postpartum hemorrhage

目的观察米索前列醇预防剖宫产产后出血的效果。方法选择160例剖宫产产妇随机分为试验组和对照组各80例。试验组于胎儿娩出后子宫肌内注射缩宫素20U,手术结束时阴道后穹窿放置米索前列醇600μg;对照组于胎儿娩出后子宫肌内注射缩宫素20U,再静脉滴注缩宫素20U。观察2组产后2h出血量及试验组用药前后血压情况。结果试验组产后2h出血量为(160.3±23.9)ml明显少于对照组的(188.9±56.5)ml,差异有统计学意义(P<0.05)。试验组用药前后收缩压和舒张压差异无统计学意义(P>0.05)。结论米索前列醇促进子宫收缩作用强于缩宫素,能较好地预防剖宫产产后出血,且用药方便、安全。

Objective To observe misoprostol for prevention of postpartum hemorrhage of cesarean section. Methods 160 eases of cesarean section were randomly divided into experimental group and control group,each of 80 cases. Experimental group intramuscular injection of fetus body temple oxytocin 20U, after the end of surgery, vaginal misoprostol dome 600μg; Con- trol group intramuscular injection of fetus body temple oxytocin 20U, then intravenous infusion of oxytocin 20U. The postpartum hemorrhage of two groups postpartum 2h and the blood pressure before and after treatment of experimental group were ob- served. Results The postpartum hemorrhage of experimental group postpartum 2h was （ 160 ± 23 ） ml lower than control group （308 ± 56 ）ml, there was a significant difference（ P 〈 0.05 ）. Systolic and diastolic blood pressure of experimental group before and after treatment was not statistically different （ P 〉 0.05 ）. Conclusion Misoprostol for uterine contraction is stronger than that of oxytocin, can better prevent bleeding after cesarean section, and the drug easily and safely.