钒酸铵氧化-分光光度法测定盐酸氯丙嗪

Spectrophotometric determination of chloropromazine hydrochloride with ammonium metavanadate as oxidizing agent

在磷酸介质中,钒酸铵与盐酸氯丙嗪反应生成红色氧化产物,其最大吸收波长为524nm;据此建立了测定盐酸氯丙嗪含量的钒酸铵氧化-分光光度法,并将其用于直接测定药物制剂中的盐酸氯丙嗪.结果表明,当盐酸氯丙嗪的浓度处于10.0～100mg/L和100～360mg/L范围内时,被测定体系的吸光度与盐酸氯丙嗪的浓度之间呈良好的线性关系;线性回归方程分别为A=-0.061 69+0.010 05c(mg/L,r=0.998 8)、A=0.494+0.004 43c(mg/L,r=0.998 8),检出限为1.96mg/L,相对标准偏差为0.29%,回收率为94.9%～102.9%.

A simple and rapid spectrophotometric method was established based on the interaction between ammonium metavanadate and chloropromazine hydrochloride（CPH） in H3PO4 solution to determine the content of CPH in medicines.It has been found that,under the optimal condition for determination,the absorbance of the tested system at the maximum absorption wavelength of 524 nm is linearly proportional to the concentration of CPH in a range of 10.0-100 mg/L and 100-360 mg/L.The linear regression equations are A=0.008 42＋0.118 44 c（mg/L,r=0.998 8） and A=0.494＋0.004 43c（mg/L,r=0.998 8）,respectively.The detection limit and relative standard deviation are 1.96 mg/L and 0.29%,while the average recovery of CPH samples is 94.9%-102.9%.