星形胶质在癫痫中的生物学机制研究进展

Progress of biological mechanisms of astrocyte in epilepsy

离子通道改变、神经递质及其受体调控异常、血脑屏障损伤、炎症、氧化应激损伤等均与癫痫发作有关。近年来通过对癫痫动物模型、癫痫患者尸体解剖或手术切除患者癫痫病灶的研究表明，星形胶质与癫痫的发生发展有一定的关系，但两者之间的因果关系一直没有定论。目前多数抗癫痫药物都是针对神经元，对患者的认知和脑功能都有一定的影响。因此，从星形胶质的角度去探讨癫痫的发病机制，有助于发现新的干预靶点以开发新型抗癫痫药物。

Many studies have shown that changes in ion channels,abnormal regulation_ of neurotransmitters and their receptors, blood-brain barrier damage, inflammation, oxidative stress etc, are all related with seizures. Animal models of epilepsy, focusing on autopsy of patients with epilepsy or pathological changes of epileptic, have found that there is a certain relationship between astrocytes and epilepsy, but the cause has remained unclear. At present, most of antiepileptic drugs work on the target of neurons, which have certain impact on the patient＇s congnitive and brain function. Therefore, to investigate the pathogenesis of epilepsy from the perspective of astcytes,it might help to identify new intervention targets for new antiepileptic drugs.