多药耐药相关蛋白与难治性癫痫发病关系的研究进展

The relationship of multi-drug resistance associated protein and refractory epilepsy

难治性癫痫的耐药机制尚不清楚。近年来研究认为与多药耐药相关蛋白关系密切，其耐药机制可能与多药耐药相关蛋白在癫痫脑组织中高表达有关，通过将药物从细胞内泵到细胞外，从而降低脑内的药物浓度而使之产生耐药性。多药耐药相关蛋白在调节癫痫患儿细胞内外抗癫痫药物浓度时发挥重要作用。其特异性抑制剂可能提高抗癫痫药在难治性癫痫中的作用，因此，对多药耐药相关蛋白的深入研究可能会为今后临床治疗难治性癫痫提供新方法及为新的抗癫痫药物的研究提供新的方向。

The mechanism of drug resistance of refractory epilepsy has remained unclear. In recent years, studies have shown that the multi-drug resistance associated protein（MRP） is related with refractory epi- lepsy. The mechanism responsible for the drug resistance may have something to do with the higher expression of MRP1 mRNA in brain tissues of refractory epilepsy patients. Through the use of drugs in cells to cells from the pump,it can reduce the drug concentration in brain and make the creation bears the medicine and inhibitors speciftc for MRP,which can significantly improve the effect of some antiepilepfic drugs. Thus, further studies may provide new ways for the treatment of refractory epilepsy and find targets for new antiepileptic drugs.