术后慢性疼痛的药物治疗

Pharmacotherapy of post-surgical pain

手术是治疗许多疾病最为有效的方法之一,但手术本身会造成组织和(或)神经的损伤,造成慢性术后疼痛综合征(chronic post-surgical pain syndrome,CPSPS),如腰椎手术失败综合征(failed back surgery syndrome,FBSS)、开胸手术后疼痛综合征(post-thoracotomy pain syndrome,PTPS),乳房切除术后疼痛综合征(post-mastectomy pain syndrome,PMPS)等。CPSPS目前常用的药物主要有非甾体消炎药、中枢镇痛药、抗癫痫药及抗抑郁药等。

Surgery is one of the most effective methods for treatment of many diseases, but can lead to tissue and/or nerve injury, which results in chronic post-surgical pain syndrome （CPSPS）, such as failed back surgery syndrome （FBSS）, post-thoracotomy pain syndrome （PTPS）, and post-mastectomy pain syndrome （PMPS）, etc. The mechanism of CPSPS is very complicated, and it＇s difficult to treat this kind of clinic syndrome. Drug therapy is still one of the most important methods to treat various CPSPS, and option of drug depends on the severity and characteristic of the pain. Currently, the most commonly used drugs include nonsteroidal anti-inflammatory drugs （NSAIDs）, opioids, and anti-epileptic drugs （AED）, etc.