2 223例安徽地区男性年龄相关前列腺特异性抗原参考值范围

Age-specific reference range for prostate specific antigen in 2 223 Anhui men

目的对2223例安徽地区参与体检的健康男性血清前列腺特异性抗原(prostate-specificantigen,PSA)水平进行分析,探讨建立安徽地区男性血清PSA的参考值范围。方法收集2010年2月至2011年5月在安徽医科大学第一附属医院进行健康体检的标本2223例,均来自无下尿路症状的健康男性,用罗氏cobas614全自动电化学分析仪及相应配套试剂进行血清PSA检测。结果 2223例健康男性的PSA均数为1.12μg/L,标准差为1.16μg/L,第一四分位数为0.59μg/L,中位数为0.90μg/L,第三四分位数为1.20μg/L,四分位间距为0.61μg/L。PSA95%可信区间为2.78μg/L;2223例中≤3.00μg/L的有2124例,占95.54%,其年龄组成≤65岁的男性为92.84%;>3.00～10.00μg/L的有91例,占4.09%;如以4.00μg/L为参考值,≤4.00μg/L的有2178例,占97.98%;>4.00～10.00μg/L的有36例,占1.61%;>10.00μg/L的有9例,占0.40%,并且各年龄组间均数差异有统计学意义。结论各个年龄组PSA水平与Oesterling标准存在差异,65岁以下人群PSA水平低于欧美及亚洲其他地区人群,65岁以上人群PSA水平高于欧美及亚洲其他地区人群,该现象提示65岁以下人群参考值设在3.00μg/L为宜,65岁以上人群可继续以4.00μg/L作为参考值。

Objective In order to establish serum PSA reference range of Chinese men by in- vestigating the PSA levels of 2 223 asymptematic healthy men in Anhui province of china. Methods 2 223 healthy samples from persons who got check-ups in the first affiliated hospital of Anhui medical university were collected from February 2010 to May 2011 and were measured by MEIA with ILMA instrument. Results The mean PSA level of 2 223 cases was 1.12 ~g/L and the standard devia- tion was 1.16 /~g/L. The first quartile was 0. 59 /~g/L and the median was 0. 90 μg/L, then the third quartile was 1.20 μg/L and the interquartile was 0. 61 btg/L. The 95% percentile was 2.78μg/L. The 95% percentile of all cases, including 2 124 cases, was less than 3.00 μg/L, and of them 92.84% were 65 years old. 91 cases was between 3.00-10.00μg/L, accounting for 4.09%. If took 4.00μg/L as reference value, 2 178 cases was less than 4.00μg/L, accounting for 97.98%, and 36 cases between 4.00-10.00 μg/L, accounting for 1.61%, and 9 cases was greater than 10.00 μg/L, ac- counting for 0.40%. The mean PSA level difference in each age group was statistically significant. Conclusions Our data show that the mean PSA level in Anhui area was 1.12μg/L and the standard deviation was 0.61 μg/L at present stage, and the 95% percentile was 2.78μg/L. The PSA levels in all age groups are different from Oesterling＇s reference values. The PSA level of Chinese men who are under 65 years old is lower than that of Euramericans and other Asians, however it is higher than them when the age is above 65 years old. This phenomenon will justify the different reference values of PSA in different age： 3.00 μg/L for those under 65 years old and 4.00 μg/L for those above 65 years old.