水飞蓟素联合复方甘草酸苷治疗妊娠合并慢性乙型肝炎的疗效观察

Observation on the therapeutic effect of silymarin and compound glycyrrhizin in the treatment of pregnant women complicating chronic type B hepatitis

目的观察水飞蓟素联合复方甘草酸苷治疗妊娠合并慢性乙型肝炎的疗效。方法将105例妊娠合并慢性乙型肝炎患者完全随机分为研究组（53例）和对照组（52例），对照组给予复方甘草酸苷注射液60ml加入5％葡萄糖注射液250ml，1次／d静脉滴注；研究组在对照组的基础上加用水飞蓟素片140rag／次，3次／d口服。结果治疗24个月后，研究组ALT、AST、TBil明显低于对照组[分别为（42±19）U／L比（51±19）U／L，（32±17）U／L比（52±13）U／L，（17±10）umol／L比（25±9）umol／L，均P〈0．05]。研究组总有效率优于对照组[90．5％（48／53）比75．0％（39／52）,X2=4．48，P〈0．05]。结论水飞蓟素联合复方甘草酸苷治疗妊娠合并慢性乙型肝炎具有安全有效的特点。

Objective To observe the therapeutic effect of Silymarin and Compound Glycyrrhizin in the treatment of Pregnant Women Complicating Chronic Type B Hepatitis. Methods One hundred and five patients were randomly divided into two groups, the treatment group （52 cases） was treated with Silymarin and Compound Glycyrrhizin, the control group （53 cases） was treated with Compound Glycyrrhizin alone. Results After 24 months of treatment , the treatment group ： ALT （42 ± 19 ） U/L, AST （ 32 ± 17 ） U/L, TBil （ 17 ± 10） umol/L ; the control group ： ALT （ 51 ± 19） U/L, AST （ 52 ± 13 ） U/L, TBil （25 ± 9 ） umol/L, and there was a statistically significant difference between the two groups （ P 〈 0.05 ） in liver function. The total efficiency of the two groups were 90.5 % （48/ 53） and 75.0% （39/52）, and there was also a statistically significant difference between the two groups（x2 = 4.48, P 〈 0.05）. Conclusion The therapeutic effect of Silymarin and Compound Glycyrrhizin in the treatment of pregnant women complicating chronic type B hepatitis is safe and effective.