儿童尿氟与骨质疏松相关性及尿氟基准剂量研究

Study on Benchmark Dose of Urine Fluoride in Children and Relationship to the Osteoporosis

目的探讨饮水型氟病区儿童骨质疏松与尿氟之间的关系。方法于2011年4月,选择固原市氟病区南屯村、马园村、南源村作为调查点,以非氟病区开城村作为对照村;在每村选择50名在当地出生的8～12岁在校小学生(2～6年级各选10名,男女各半)共200名。测定水氟浓度和小学生尿氟与骨密度。结果氟病村的水氟浓度均高于对照村,且均发现有小学生发生骨质疏松。小学生骨质疏松发生率(y)与尿氟浓度(x)的拟合方程为y=1/(1+e3.407-0.369x),尿氟的基准剂量和基准剂量下限分别为2.59、1.67 mg/L。结论本次调查的固原市氟病区小学生骨质疏松的发生率随着尿氟的升高而上升。

Objective To explore the relationship between the osteoporosis and fluoride contents in urine in the children in dringking water-borned fluorosis areas. Methods A total of 200 children aged from 8 to 12 in four primary schools in different villages were investigated in Guyuan, Ningxia province in April, 2011. The three villages in flurosis areas and one village in non-flurosis. A total of 50 children were chosen from a village. 10 children, 5 male and 5 female, were chosen from each class from 2 to 6 grade in the school. The bone density of every children was measured and the fluoride content in drinking water and urine were determined. Results The fluoride contents in water in the villages in fluresis are~,s were higher than that in the non-fluresis areas and a few children in the villages in flurosis areas were suffering osteoporosis. The fitting equation of the rate of osteoporosis and the urine fluoride was y=1/（1＋e^3.407-0.369x）. The BMD of urine fluoride was 2.59 mg/L. The BMDL of urine fluoride was 1.67 mg/L. Conclusion The rate of osteoporosis will rise when urine fluoride increases in children in flurosis areas in Guyuan, Ningxia.