金属及金属氧化物纳米颗粒致海马神经元毒性的研究进展

Research Advance on Toxicity of Metal and Nanoparticles of Metal Oxide to Hippocampal Neurons

随着纳米技术的迅速发展和纳米材料的广泛使用,纳米材料的生物安全性研究已成为研究热点。中枢神经系统是金属及金属氧化物纳米材料的靶器官之一,且大脑海马区是损伤最严重的部分。该文综述了金属及金属氧化物纳米材料损伤海马神经元的直接和间接途径以及损伤的效应机制,如氧化应激、炎症反应、氧化应激和炎症反应的协同损伤作用及细胞膜离子通道门控改变,并探讨了金属及金属氧化物纳米颗粒致海马神经元毒性研究中存在的问题,以期为后续研究提供线索。

With the rapid development of nanotechnology and the widely use of nano-materials,the study of safety of nano-materials has become a hot research area. Some studies have found that the central nervous system was one of the target organs of the metal and nanomaterials of metal oxide, and the brain hippocampus was the most selious part of the damage; the review described the direct and indirect ways of metal and nanomaterials of metal oxide damage on hippocampal neurons, and the damage effects and mechanisms, such as oxidative stress, inflammatory reaction, and the synergistic effect of oxidative stress and inflammatory responses and the change of cell membrane ion channel door control. To provide clues for further research, the existing problems in the toxicity studies of metal and nanoparticles of metal oxide on hippocampal neurons were explored in this paper.