泌尿生殖道支原体感染238例及药敏结果分析

Infection and drug resistance analysis of 238 urogenital tract mycoplasma

目的通过分析2009～2010年度在我院就诊的非淋球菌性泌尿生殖道炎症(NGU)患者支原体感染及耐药性情况,以指导临床合理用药。方法对528例泌尿生殖道感染患者的尿道(宫颈)分泌物采用支原体培养鉴定、药敏一体试剂盒进行检测。结果共检出支原体感染阳性238例,阳性率为45.07%,女性感染率比男性高,Uu单独感染率为77.73%。Uu对司帕沙星、壮观霉素和左旋氧氟耐药率2年间有显著性变化(P<0.01)。Uu+Mh仅对左旋氧氟耐药率2年间有显著性变化(P<0.01)。泌尿生殖道支原体药物敏感率前3位为美满霉素、强力霉素和交沙霉素。结论本地区泌尿生殖道支原体感染耐药性严重,首选药物为美满霉素、强力霉素或交沙霉素。治疗必须根据药敏结果以合理用药,减少耐药株的产生。

Objective To analyze the infection and drug resistance of urogenital tract mycoplasma from 2009 to 2010 in the First People＇s Hospital of Chuzhou so as to guide the rational medication. Methods The secretion specimens collected from 528 patients with non-gonoccocal urethritis（NGU） were tested by one complex kit including mycoplasma~ culture. Re- suits 238 cases were infected with mycoplasma. The positive rate was 45.07%. The infection rate in female patients was sig- nificantly higher than that in male patients. The infection rate of ureaplasma urealyticum （ Uu） was 78.15%. The sensitive rate of Uu to sparfloxacin, spectinomycin and levofloxacin was significantly decreased in two years （ P 〈 0.01 ）. Uu ＋ Mh was only drug sensitive to levofloxacin. The rate was significantly decreased in two years （ P 〈 0.01 ）. The sensitive rate of them to mino- cycline,doxycycline or josamycin was rather higher. Conclusion The situation of drug resistance to medication in urogenital tract mycoplasma is serious. The first choices of drugs should be minocycline, doxycycline or josamycin. It＇s urgent to attach im- portance to reasonable medication to avoid the occurrence of drug-resistance to mycolplasma.