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炎症反应,健康卫士还是癌症帮凶? 被引量:1

Inflammation,Promoting Cancer or Protecting the Body Against Cancer?
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摘要 任何事物都具有两面性,炎症反应也不例外。作为生物体内最常见的生理反应之一,炎症反应不仅可以消除细菌、病毒等外界因素的入侵,还是免疫系统用于清除病变细胞的工具,从而保证机体健康;另一方面,炎症可以促进肿瘤的发展、转移和恶变。解析炎症反应和癌症的关系,了解其中的分子机制,有助于发展新的预防和治疗癌症的方法。 genesis and tumor development. While it plays an im- portant role in promoting cancer, inflammation is a ma- jor defense mechanism of the immune system in protec- ting the body against cancer as well as infection. The relationship between inflammation and tumor in different stages of cancer development is a key issue in cancerstudy. The aim of our 973 project is to gain a better un- derstand of the role of inflammatory signaling pathways and thereby provides new ideas for preventing and trea- ting cancers.
出处 《中国基础科学》 2012年第2期11-14,共4页 China Basic Science
基金 国家973计划(2009CB522200)
关键词 炎症 癌症 免疫 inflammation cancer immune system
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  • 1Kumar S, McDonnell PC, Gum R J, et al. Novel homologues of CSBP/p38 MAP kinase: activation, substrate specificity and sensitivity to inhibition by pyridinyl imidazoles. Biochem Biophys Res Commun 1997; 235:533-8.
  • 2Hanks SK, Hunter T. The eukaryotic protein kinase superfamily:kinase (catalytic) domain structure and classification. FASEB J 1999; 9:576-96.
  • 3Han S J, Choi KY, Brey PT, Lee WJ. Molecular cloning and characterization of a Drosophila p38 mitogen-activated protein kinase. J Biol Chem 1998; 273:369-74.
  • 4Brewster JL, de Valoir T, Dyer ND, Winter E, Gustin MC. An osmosensing signal transduction pathway in yeast. Science 1993;259:1760-3.
  • 5Shiozaki K, Russell P. Cell-cycle control linked to extracellular environment by MAP kinase pathway in fission yeast. Nature 1995; 378:739-43.
  • 6Shiozaki K, Russell P. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev 1996; 10:2276-88.
  • 7Freshney NW, Rawlinson L, Guesdon F, et al. Interleukin-1activates a novel protein kinase cascade that results in the phosphorylation of Hsp27. Cell 1994; 78:1039-49.
  • 8Lee JC, Laydon JT, McDonnell PC, et al. Identification and characterization of a novel protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994; 372:739-46.
  • 9Ge B, Gram H, Di Padova F, et al. MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. Science 2002; 295:1291-4..
  • 10Wang W, Chen JX, Liao R, et al. Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence. Mol Cell Biol2002; 22:3389-403.

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