阿尔茨海默病早期诊断的血液生物标记物研究进展

Biomarkers in Blood for Early Diagnosing Alzheimer’s Disease

目前研究发现:①在认知功能损害前10年,阿尔茨海默病(AD)的病理生理进程已经开始,该部分人群称之为临床前AD;②在轻度认知功能障碍(MCI)患者随访中发现,部分患者可进展为AD,对这些人群进行早期诊断和干预,可能有效遏制或延缓其进展为AD。目前,AD早期诊断的研究主要聚焦在颅脑影像学及体液生物标记两方面,其中血液生物标记因标本获取简便,与AD病理过程联系较紧密,诊断敏感度及特异度较高而倍受关注,本文就早期诊断AD潜能的血液生物标记物研究进展进行综述。

Alzheimer＇ s disease （AD） is the most common cause of dementia among older people. Although the pathogenesis of AD is still not fully understood, it has been well acknowledged that intervention should be taken at early stage of the disease. Therein, identifying biomarkers for early diagnosis of AD is critical at present. The results in the search for candidate biomarkers derived from blood, including the limitations and the perspectives of the field, were summarized.