比卡鲁胺合成路线图解
Graphical Synthetic Routes of Bicalutamide
摘要
比卡鲁胺（bicalutamide，1），化学名为（4-）-N-[4-氰基-3-（三氟甲基）苯基]-3-[（4-氟苯基）磺酰基]-2-羟基．2一甲基丙酰胺，是由英国AstraZeneca公司开发的非甾体雄激素拮抗剂，1995年在英国获准上市，主要用于治疗前列腺癌。研究表明（R）．比卡鲁胺（2）的抗雄激素活性是（S）．型异构体3的60倍，且肝代谢较慢，有利于减轻肝脏负担。
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
2012年第8期713-717,共5页
Chinese Journal of Pharmaceuticals
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