PCR理论模拟研究进展

Advances in simulation of PCR

聚合酶链反应目前已成为分子生物学领域的一个重要诊断工具,此技术使得基因组学和分子生物学的研究发生了革命性的变化。其实验条件的优化也被生物工程领域看作一个重要问题。本文回顾了基于动力学模型的计算方法开展PCR过程模拟研究的进展,PRC模拟研究有助于准确快速地获得PCR最优实验条件,对指导实验过程和PRC机理研究,有一定指导意义。

Polymerase chain reaction （PCR） is an important diagnosis tool in molecular biology, which have been greatly improved by PCR. However, optimizing the experimental conditions is still a problem for PRC. Computer biology can be a solution to this problem. In this paper, developments of the mathematical models for PCA are reviewed. It is believed that this kind of research efforts shall be helpful for optimizing the experimental conditions and providing guidance for the biologists and understanding the mechanism of PCR.