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肿瘤转移消失蛋白在直肠癌组织中的表达 被引量：3

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摘要 肿瘤转移消失（MIM）蛋白又称肿瘤转移抑制（MTSS1）蛋白，与多种肿瘤的生长转移过程密切相关。本研究旨在观察MIM蛋白在直肠组织中的表达，并分析其对直肠癌的临床意义。
作者 李金海 戴华卫 张海峰 孙广正 翟华伟
机构地区 温州医学院附属第三医院普通外科
出处 《中华实验外科杂志》 CAS CSCD 北大核心 2012年第7期1302-1302,共1页 Chinese Journal of Experimental Surgery
关键词 肿瘤转移抑制 直肠癌组织 M蛋白 生长转移 临床意义 肠组织
分类号 R735.37 [医药卫生—肿瘤]
  • 相关文献

参考文献4

  • 1黄修燕,黄自丽,汤钊猷,郑起,叶胜龙.转移消失蛋白在肿瘤发生发展中的作用[J].肿瘤,2010,30(2):170-172. 被引量：10
  • 2Lee YG,Macoska JA, Korenchuk S, et al. MIM, a potential metastasis suppressor gene in hladder cancer. Neoplasia,2002, 4 : 291 -294.
  • 3Xie F, Ye L,Ta M, et al. MTSS1 : a multi- flmctional protein and its role in cancer in- vasion and metastasis. Front Biosci (Schol Ed) ,2011,3:621-631.
  • 4Ma S, Guan XY, Lee TK, et al. Clinieo- pathological significance of missing in me- tastasis B expression in hepatocellular car- cinoma. Hum Pathol, 2007, 38: 1201- 1206.

二级参考文献26

  • 1CALLAHAN CA, OFSTAD T, HORNG L, et al. MIM/BEG4, a sonic hedgehog-responsive gene that potentiates gli-dependent transcription [ J ]. Genes Dev, 2004, 18 ( 22 ) : 2724-2729.
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  • 4SCITA G, CONFALONIERI S, LAPPALAINEN P, et al. IRSp53 : crossing the road of membrane and actin dynamics in the formation of membrane protrusions [J]. Trends Cell Boil, 2008, 18 (2) : 52-60.
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  • 6LIN J, LIU J, WANG Y, et al. Differential regulation of cortactin and N-WASP-mediated actin polymerization by missing in metastasis (MIM) protein [J]. Oncogene, 2005,24 (12): 2059-2066.
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共引文献9

同被引文献42

  • 1孙燕.五十年来我国临床肿瘤学的发展、现状和策略[c]//中国临床肿瘤教育专辑(2009).北京:中国协和医科大学出版社,2009:1-2.
  • 2Garcia M, Jemal A,Ward EM, et al. Global cancer facts and fig- ures 2007. Atlanta: American Cancer Society, 2007 : 25-26.
  • 3Debies MT, Welch DR. Genetic basis of human breast cancer me- tastasis. J Mammary Gland Biol Neoplasia, 2001,6 ( 4 ) :44 ! -451.
  • 4Lee YG, Macoska JA, Korenchuk S, et al. MIM, a potential me- tastasis suppressor gene in bladder cancer. Neoplasia,2002,4 (4) : 291-294.
  • 5Parr C, Jiang WG. Metastasis suppressor 1 ( MTSS1 ) demonstrates prognostic value and anti-metastatic properties in breast cancer. Eur J Cancer,2009,45 (9) : 1673-1683.
  • 6Mattila PK, Salminen M, Yamashiro T, et al. Mouse MIM, a tis- sue-specific regulator of cytoskeletal dynamics, interacts with ATP- actin monomers through its C-terminal WH2 domain. J Biol Chem, 2003,278 (10) :8452-8459.
  • 7Ma S, Guan XY, Lee TK, et ai. Clinicopathological significance of missing in metastasis B expression in hepatocellular carcinoma. Hum Patho1,2007,38 ( 8 ) : 1201-1206.
  • 8Machesky LM, Johnston SA. MIM : a muhifunctional scaffold pro- tein. J Mol Med (Berl),2007,85(6) :569-576.
  • 9Wang Y, Liu J, Smith E, et al. Downregulation of missing in me-tastasis gene (MIM) is associated with the progression of bladder transitional carcinomas. Cancer Invest ,2007,25 ( 2 ) :79-86.
  • 10Saarikangas J, Mattila PK, Varjosalo M, et al. Missing-in-metas- tasis MIM/MTSS1 promotes actin assembly at intercellular junc- tions and is required for integrity of kidney epithelia. J Cell Sci, 2011,124(Pt 8) :1245-1255.

引证文献3

二级引证文献5

中华实验外科杂志
2012年 第7期

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