肝硬化患者左右半肝纤维化及肿瘤坏死因子-α和白细胞介素-6的研究

Left and right half-liver fibrosis and expression of tumor necrosis factor-α and interleukin-6 in in hepatic cirrhosis

目的观察乙型肝炎肝硬化患者左右半肝体积及肿瘤坏死因子（TNF）-α和白细胞介素（IL）-6的表达，探讨肝硬化患者左右半肝硬化程度。方法对45例乙型肝炎肝硬化患者和15例正常对照组的肝体积及TNF-α和IL-6进行分析。结果45例肝硬化患者中右半肝萎缩较左半肝萎缩明显增多（P〈0．01）。TNF-α在病例组右半肝的表达明显高于病例组左半肝的表达，差异有统计学意义（x2=30．42，P〈0．01），IL-6在病例组右半肝表达明显高于病例组左半肝表达，差异有统计学意义（x2=16．20，P〈0．01）。结论肝硬化时左右半肝纤维化程度存在明显差异，右半肝较左半肝纤维化程度显著。

Objective To investigate the morphous of left and right half-liver cirrhosis and the ex- pression of tumor necrosis factor （TNF） -α and interleukin （IL） -6. Methods The liver volume, TNF-α and IL-6 were analyzed in 45 specimens of patients with liver cirrhosis and 15 specimens of controls. Resuits In the 45 cases of liver cirrhosis, the right lobe of liver had a more significant sign of atrophy than the left lobe of liver. The expression of TNF-α in the patients group was more obvious than that in the control group （X2 =30.42,P 〈0. 01 ）. The expression of IL-6 in the patients group was significantly higher than in the control group （X2 = 16. 20, P 〈 0.01 ）. Conclusion The difference in the degree of left and right half-liver hepatic fibrosis in hepatic cirrhosis was significant. There is a close relationship between TNF-α, IL-6 and left and right half-liver fibrosis in hepatic cirrhosis. This research provides some new the- oretical basis for the location and the size of the surgical excision of hepatocarcinoma with cirrhosis.