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P-选择素对Apc^(Min/+)小鼠肠道肿瘤的作用 被引量：2

Role of P-selectin in intestinal tumorigenesis in Apc^(Min/+) mice
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摘要 目的:研究P-选择素(P-selectin)在ApcMin/+小鼠肠道肿瘤中的作用。方法:采用P-selectin基因缺失的基因工程小鼠和肠道肿瘤模型ApcMin/+小鼠杂交,计数ApcMin/+小鼠与ApcMin/+P-selectin-/-杂交小鼠小肠及大肠肿瘤的数目,并测量其肿瘤体积,研究P-selectin对ApcMin/+小鼠肠道肿瘤的作用。结果:与ApcMin/+小鼠相比,ApcMin/+P-selectin-/-杂交小鼠在9周龄时肠道肿瘤数目与总负荷明显减少。结论:P-selectin缺失能够显著抑制ApcMin/+小鼠肠道肿瘤的生长。 AIM： To investigate the role of P- selectin in intestinal tumorigenesis in Apc^Min/＋ mice （ C57BL/ 6J-Apc^Min/＋/J）. METHODS： Female P- selectin knockout mice （]36. 129S7 -Selp^tmlBay/J, that was P- selectin-/-） were mated with male Apc^Min/＋ mice. The offspring was genotyped for Min＋/- and P-selectin null mutantions, which were Apc^Min/＋ P - selectin-/- mice. The tumor number and gross tumor volume in the small and large intestines of theApc^Min/＋＋ P-selectin-/- mice and Apc^Min/＋ mice were determined. REULTS： P -seleetin deficiency in Apc^Min/＋ mice resulted in significant decreases in the tumor number and gross tumor volume in the small intestine and total intestine. CONCLU- SION： Deletion of P -selectin significantly inhibits the tumorigenesis in mouse intestines. In addition, the results also sug- gest that P - selectin may be a marker for colon cancer.
作者 郭四美 亓翠玲 叶杰 周秦 王丽京
机构地区 广东药学院血管生物学研究所
出处 《中国病理生理杂志》 CAS CSCD 北大核心 2012年第7期1197-1201,共5页 Chinese Journal of Pathophysiology
基金 科技部"973"项目国家重点基础研究发展计划(No.2010CB529702) 国家青年基金资助项目(No.30900764)
关键词 P-选择素 基因工程小鼠 肠道肿瘤 P- selectin Genetically engineered mice Intestinal neoplasms
分类号 R363.2 [医药卫生—病理学] R735.3 [医药卫生—肿瘤]
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参考文献24

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二级参考文献11

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共引文献8

同被引文献17

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引证文献2

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中国病理生理杂志
2012年 第7期

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