不同类型冠心病患者肿瘤坏死因子和白细胞介素-8的表达水平及其临床意义

TNF-α and IL-8 expression level and their clinical meaning on different types of coronary artery disease

目的探讨不同类型冠心病患者肿瘤坏死因子-α(TNF-α)和白细胞介素-8(IL-8)的表达水平及其临床意义。方法选择经冠脉造影确诊的冠心病患者176例,将其分为稳定型心绞痛(SAP)组48例、不稳定型心绞痛(UAP)组85例和急性心肌梗死(AMI)组43例,另选50例健康成人为对照组,检测研究对象的血常规、肝肾功能、血糖、血脂、TNF-α及IL-8等,所有冠心病患者经冠脉造影检查后明确冠状动脉病变支数和冠脉Gensini积分情况,比较各组TNF-α和IL-8水平,并分析其与冠心病患者病情程度和冠状动脉的病变程度。结果冠心病三组中TNF-α和IL-8水平均明显高于对照组(P<0.01),UAP组中TNF-α和IL-8水平明显高于SAP组(P<0.01),AMI组中TNF-α和IL-8水平明显高于UAP组(P<0.01),在冠心病患者中双支病变组TNF-α和IL-8水平明显高于单支病变组(P<0.01),而多支病变组TNF-α和IL-8水平也显著高于双支病变组(P<0.01),Gensini积分越高,TNF-α和IL-8水平也越高(P<0.01),TNF-α和IL-8水平与冠脉Gensini积分呈正相关(r分别为0.694、0.669,P<0.01),且IL-8和TNF-α之间呈正相关关系。结论冠心病患者TNF-α和IL-8水平明显增高,两者之间有密切相关,临床上检测TNF-α和IL-8可预测冠心病患者病情严重程度和冠状动脉的病变程度。

Objective To explore the TNF-α and IL-8 expression level and their clinical meaning on different types of coronary artery disease.Methods 176 patients with coronory heart disease（CHD） diagnosed by Coronarography（CAG） were chose and divided into stable angina pectoris（SAP） group with 48 patients,unstable angina pectoris（UAP） group with 85 patients and acute myocardial infarction（AMI） group with 43 patients,and 50 healthy people were chose as control group.To determine blood routine,liver and renal function,blood sugar,TNF-α and IL-8 for all the subjects.All the CHD patients were definite known diseased coronary vessels by CAG and coronory Gensini integral.To compare TNF-α and IL-8 among every group and its relationship with diseased coronary vessel,and analyse their relationship with patient＇s condition and Coronary artery disease severity.Results TNF-α and IL-8 of three subgroups of CHD are significant higher than that in contorl group（P0.01）,so does TNF-α and IL-8 in UAP group than SAP group（P0.01）.TNF-α and IL-8 in AMI group are higher than UAP group（P0.01）.The TNF-α and IL-8 of double diseased coronory vessels are all higher than single diseased（P0.01）,and which in many diseased coronory vessels group are higher than the former（P0.01）.In the three different Gensini groups,Gensini integral is consistent rise with TNF-α and IL-8（P0.01）.There is obviously positive correlation between TNF-α and IL-8 level and coronary Gensini integral（ris 0.694、0.669,P0.01）,so does the relationship between TNF-αandIL-8.Conclusion TNF-α and IL-8 of in patients with CHD increase obviously.There is closely relationship between them.Clinical examination of TNF-αandIL-8 can preliminary forecast the patients＇ condition and coronary artery stenosis degree.