摘要
目的研究在复发性阿弗他溃疡(RAU)患者唾液中肿瘤坏死因子(TNF-α)的表达及临床意义。方法用双抗体夹心ELISA法对RAU患者38例(男21例,女17例,年龄15～56岁)唾液中TNF-α的含量进行检测,并以38例(男19例,女19例,年龄18～50岁)健康人做正常对照,对结果进行定量分析。结果 38例RAU患者唾液中TNF-α的平均含量(82.86±21.63)pg/mL比健康人(55.34±17.50)pg/mL明显升高(t=3.877,P<0.001)。结论 TNF-α的含量在RAU患者唾液中明显高于健康对照组,说明TNF-α参与了RAU的病理过程。
Objective To study the expression and clinical significance of tumor necrosis factor α（TNF-α） of saliva in patients with recurrent aphthous ulceration（RAU）.Methods Salivary levels of TNF-α in 38 patients（male21,female17,aged 15~56 years） with RAU were determined by double-antibody sandwich ELISA,salivary of 38（male19,female19,aged18-50 years）healthy individuals served as controls.Results The mean salivary TNF-α level in RAU patients（82.86±21.63） pg/ml was significantly higher than that in the controls（55.34±17.50）pg/ml,（t=3.877,P0.001）.Conclusion The salivary TNF-α level in RAU patients is significantly increased,which indicates further that TNF-α may play a very important role in the pathogenesis of RAU.
出处
《中国实验诊断学》
2012年第7期1216-1218,共3页
Chinese Journal of Laboratory Diagnosis
关键词
肿瘤坏死因子
复发性阿弗他溃疡
唾液
tumor necrosis factor
recurrent aphthous ulceration（RAU）
saliva
