3-溴-1,6-萘啶-5(6H)-酮的合成

Synthesis of 3-bromo-1,6-naphthyridin-5(6H)-one

报道了以1,1,3,3-四甲氧基丙烷和2-氰基乙酰胺为起始原料,经胺化、溴化、Sonogashira选择偶联、氰基水解等反应合成5-溴-2-(2,2-二甲氧基乙烯基)-烟碱酰胺(8),8经环化反应得到化合物3-溴-1,6-萘啶-5(6 H)-酮(9),共历经8步反应,总产率约为10%.化合物(9)的结构经过1 HNMR、13 C NMR、MS和EA等表征.

The new compound 3-bromo-1,6-naphthyridin-5 （6H）-one was synthesized in the total yield of 10% after eight reactions, by the cyclization of the compound 7 under the catalysis of the Tol-OH. The compound 7 was prepared from 1,1,3,3-tetramethoxypropane and 2-cyanoacetamide by amidation, bromination, Sonogashira selective coupling, hydrolyzation of cyanide. The structure of compound 9 was confirmed correctly by 1H NMR,13C NMR, MS and EA.