阑尾炎患者血清免疫球蛋白及多项白介素、CRP、ICAM-1、TNF-α水平研究

Study on Levels of Serum Immunoglobulin,IL-6,IL-8,IL-10,CRP,ICAM-1,and TNF-α in Patients with Appendicitis

目的探讨阑尾炎患者血清免疫球蛋白及多项白介素、CRP、ICAM-1、TNF-α水平的变化规律。方法选取2009年1月-2011年5月于本院进行治疗的82例阑尾炎患者为研究对象,将其设为观察组,同时选取82名健康人为对照组,将两组人员的免疫球蛋白、血清IL-6、IL-8、IL-10及CRP、ICAM-1、TNF-α水平进行统计及比较。结果观察组IgM(1.88±0.17)g/L、IgG(12.75±1.29)g/L、IL-6(126.42±15.43)pg/ml、IL-8(131.68±27.84)ng/ml、IL-10(59.97±4.52)pg/ml及CRP(11.08±1.29)mg/L、ICAM-1(440.57±24.65)ng/ml、TNF-α(154.37±25.6)ng/ml水平均高于对照组,IgA(5.62±1.01)g/L水平低于对照组,差异均有统计学意义(P<0.05)。结论阑尾炎患者血清免疫球蛋白及多项白介素、CRP、ICAM-1、TNF-α水平呈现一定的变化规律,可为其治疗诊断提供依据。

Objective To explore the variation of serum immunoglobulin IL-6,IL-8,IL-10,CRP,ICAM-1,and TNF-α in patients with appendicitis.Methods Eighty-two patients with appendicitis hospitalized in the People＇s Hospital of Rongcheng County from January 2009 to May 2011 were selected as the research objects and served as observation group.82 healthy individuals were simultaneously selected as control group.The levels of immunoglobulin,IL-6,IL-8,IL-10,CRP,ICAM-1,and TNF-α were analyzed and compared between the two groups.Results The levels of IgM（1.88±0.17） g/L,IgG（12.75±1.29） g/L,IL-6（126.42±15.43） pg/ml,IL-8（131.68±27.84） ng/ml,IL-10（59.97±4.52） pg/ml and CRP（11.08±1.29） mg/L,ICAM-1（440.57±24.65） ng/ml,TNF-α（154.37±25.6） ng/ml in observation group were all higher than those in control group,while the level of IgA（5.62±1.01） g/L was lower than that of control group,there were statistically significant differences between the two groups（all P0.05）.Conclusions The change of serum immunoglobulin,IL-6,IL-8,IL-10,CRP,ICAM-1,and TNF-α of patients with appendicitis shows its rule,and it can provide the evidence for treatment and diagnosis of the disease.