喜炎平与炎琥宁佐治小儿急性支气管炎临床疗效评价

Clinical Curative Effect Evaluation of Xiyanping and Yanhuning Injection in the Adjuvant Treatment of Acute Bronchitis in Children

目的：评价喜炎平与炎琥宁两种穿心莲内酯注射剂治疗小儿急性支气管炎的临床效果。方法：将符合纳入标准的360例小儿急性支气管炎病例随机分为喜炎平组、炎琥宁组和对照组各120例，三组患儿治疗前临床症状和体征基本相同。对照组给予一般治疗，喜炎平组在一般治疗基础上，给予静脉滴注喜炎平注射液5mg／（kg·d），炎琥宁组在一般治疗基础上，给予静脉滴注炎琥宁10mg／（kg·d），1；L／d，疗程5～7d，观察三组患儿的发热、咳嗽、咳痰、肺部哆音等临床症状体征改善情况以及不良反应。结果：喜炎平组治疗总有效率为92．5％（111／120），炎琥宁组治疗总有效率为74．2％（89／120），对照组治疗总有效率65．8％（79／120），喜炎平与炎琥宁组总有效率比较差异有统计学意义（χ^2=6．05，P〈0．05）；两组不良反应发生率比较差异有统计学意义（χ^2=4．86，P〈0．05）。结论：喜炎平治疗小儿急性支气管炎，可迅速缓解症状，并缩短病程，临床效果及安全性优于炎琥宁。

Objective：To evaluate clinical effect of two andrographis panicuha lactone injection （Xiyanping and Yanhuning injection） in the adjuvant treatment of acute bronchitis in children. Methods： Three hundred and sixty cases were randomly divided into three groups： Xiyanping group （120 cases）, Yanhuning group （120 cases）, and the control group （120 cases）. Clinical symptoms and signs of the three groups before treatment were the same. All the groups were given basic treatment ; Xiyanping group were given Xiyanping injection 5 mg/（ kg ·d） once a day, 5 to 7 days ; Yanhuning group were given Yanhuning injection 10 mg/（ kg·d） once a day, 5 to 7 days. Clinical symptoms, signs and side effects of the three groups were observed and recorded. Results： The total effective rates of Xiyanping group, Yanhuning group and the control group were 92.5% （111/120）, 74.2% （89/120） and 65.8% （79/120）, respectively. There was a remarkable difference between Xiyanping group and Yanhuning group （P〈0.05）. The adverse reactions were statistically significant between Xiyanping group and Yanhuning group （ P 〈 0.05 ）. Conclusions： Xiyanping injection can rapidly alleviate the symptoms, and shorten the course of acute bronchitis. The clinical effect and safety of Xiyanping are better than those of Yanhuning.