氨基比林原料药含量测定方法的研究

Amidopyrine drug study on the determination of the capacity

氨基比林属吡唑酮类解热镇痛药,其通过选择性的抑制下丘脑前部前列腺合成酶,减少前列腺素的生物合成,使体温恢复正常,而实现疗效。目前现行法定标准是用容量分析法来测定氨基比林的含量,但该法终点无明显突跃,难以准确判断。本实验通过紫外分光光度法直接测定氨基比林原料药中氨基比林的含量,其操作简便、快速、可行,通过对两种方法的简单比较说明紫外分光光度法测得的结果准确度较高。

Amidopyrine is the antipyretic analgesics of pyrazole ketones, which through selective inhi- bition of prostate anterior hypothalamus synthase to reduce the biosynthesis of prostaglandins. So the body tem- perature returned to nornal and achieve the effect. At present, the existing legal standards of capacity analysis is used to determine the content of aminopyrine, but the end of the act no significant jump, it is difficult to determine accurately. This experiment with the use of Amidopyrine reductive to Fe3 ＋ reduced to Fe2 ＋, and Fe2 ＋ can be with the o-phenanthroline to form a red complex, followed by direct determination Absorptiophotome- try drug in its content of aminopyrine, and two ways to make a simple comparison.