轮状病毒肠炎致患儿心肌损害的临床研究

Clinical analysis of the Myocardial Injury Caused by Rotavirus Enteritis in Infants

目的探讨轮状病毒肠炎对患儿心肌损害的临床特点。方法将76例粪便轮状病毒(Rotavirus,RV)抗原阳性患儿作为观察组,将同期住院的RV抗原阴性的72例肠炎患儿作对照组,将两组的心肌酶谱、心电图及超声心动图结果进行对比分析。结果轮状病毒肠炎组患儿心肌酶谱各指标明显高于非轮状病毒肠炎组(P<0.01),心电图异常率也明显高于对照组(P<0.01);超声心动图所测左心室射血分数(EF)、左室短轴缩短率(FS)两组之间无明显差异。结论轮状病毒肠炎较非轮状病毒肠炎更容易出现心肌损害。通过检测患儿心肌酶谱、心电图和超声心动图等指标,动态观察其变化,对轮状病毒所致心肌损害的早期诊断及治疗有重要的临床意义。

Objective To investigate the characteristic of the myocardial injury caused by rotavirus en- teritis in infants. Methods Seventy-six infants of stool rotavirus antigen positive were sampled as observation group and seventy-two infants of stool rotavirus antigen negative were sampled as control group. All the infants were phlebotomized to detect serum levels of AST, CK, CK-MB, LDH, ct-HBDH, and also were checked by e- lectrocardiogram （ECG） and Doppler ultrasound echocardiography （UCG）. Results The myocardial enzyme level and the rate of abnormal ECG of the observation group were significantly higher compared with that of the control group （P 〈 0. 01 ）. The differences of ejection fraction （EF） and fractional shortening（FS） detected by UCG between two groups were not significant （P 〉 0. 05 ）. Conclusion The rate of myocardial injury in the in- fants with rotavirus enteritis is higher than which with non-rotavirus enteritis. To observe the serum myocardial enzyme and the index of ECG and UCG is very important to diagnosis and cure myocardial injury in early days.