2型糖尿病下肢血管病变与血清胱抑素C的关系

The relationship between lower extremities arterial disease(LEAD)in type 2 diabetes mellitus and serum cystatin C

目的研究2型糖尿病(T2DM)合并下肢血管病变患者的临床特点及其与血清胱抑素C(CysC)的关系。方法将103例住院T2DM患者根据有无合并下肢血管病变分为合并下肢血管病变组和无下肢血管病变组,记录患者身高、体重、腰围、臀围,进行空腹血糖(FBG)、血总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、血清肌酐(Scr)、血清胱抑素C(CysC)、空腹胰岛素(FINS)测定,计算体重指数(BMI)、腰臀比(WHR)、胰岛素抵抗指数(HOMA-IR)。结果 2型糖尿病合并下肢血管病变组BMI、WHR、FINS、HOMA-IR、LDL-C、CysC较无下肢血管病变组升高(P<0.05),而FBG、TC、HDL-C、TG两组差别无统计学意义(P>0.05)。结论 2型糖尿病合并下肢血管病变组更易出现血脂异常及胰岛素抵抗。2型糖尿病合并下肢血管病变组胱抑素C水平较高。

Objective To investigate the relationship between between lower extremities arterial dis- ease（LEAD） in type 2 diabetes mellitus and serum cystatin C （CysC）. Methods 103 cases of T2DM were di- vided into 2 groups with LEAD and without LEAD. Their body height, weight, waist, hip were recorded ;the lev- els of fasting blood glucose （ FBG）, serum total cholesterol （TC） , serum high density lipoprotein （ HDL-C ）, ser- um low density lipoprotein （LDL-C）, serum triglyceride（ TG）, serum creatinine（ Scr）, serum cystatin C（CysC） and fasting serum insulin（FINS） were determined, body mass index（ B MI）, the waist to hip ratio （WHR）and in- sulin resistance index （HOMA-IR） were calculated. Results. Results The levels of BMI, WHR, FINS, HOMA- IR, LDL-C and CysC increased significantly in LEAD group compared with non2 LEAD group （P 〈 0.05 ）, the levels of FBG, TC, HDL-C and TG had no statistical significance between two groups （ P 〉 0. 05 ）. Conclusion LEAD in T2DM patients had remarkable dyslipidemia, insulin resistance and higher CysC.