期刊文献+

亲环素A在心血管疾病中作用的研究进展 被引量:5

下载PDF
导出
摘要 亲环素A(cyclophilin A,CyPA)是一种在生物界广泛存在、高度保守的蛋白质,其具有肽酰脯氨酰顺反异构酶活性,在细胞内充当分子伴侣作用,参与蛋白折叠、组装,以及胞内运输、信号传导等。而细胞外亲环素A作为一种氧化应激诱导分泌因子,在心血管疾病的病理生理过程中有重要作用,为其临床研究、治疗提供新的方向和靶点。
出处 《岭南心血管病杂志》 2012年第4期444-447,共4页 South China Journal of Cardiovascular Diseases
  • 相关文献

参考文献27

  • 1HANDSCHUMACHER R E, HARDING M W, RICE J, et al. Cyclophilin: a specific cytosolic binding protein for cyclosporin A[J]. Science, 1984, 226(4674): 544-547.
  • 2WANG P, HEITMAN J. The cyclophilins [J]. Genome Biol, 2005, 6(7): 226.
  • 3THIRIAULT Y, LOGAN T M, MEADOWS R, et al. Solution structure of the cyclosporin A/cyclophilin complex by NMR [J]. Nature, 1993, 361(6407): 88-91.
  • 4SMART E J, YING Y, DONZELL W C, et al. A role for caveolin in transport of cholesterol from endoplasmic reticulumto plasma membrane[J]. J Biol Chem, 1996, 271(46) : 29427- 29435.
  • 5SATOH K, SHIMOKAWA H, BERK B C. Cyclophilin A: promising new target in cardiovascular therapy[J]. Circ J, 2010, 74( 11 ) : 2249-2256.
  • 6DAMSKER J M, BUKRINSKY M I, CONSTANT S L. Preferential chemotaxis of activated human CD4 + T cells by extracellular cyclophilin A [ J ]. J Lenkoc Biol, 2007, 82 (3) : 613-618.
  • 7SONG F, ZHANG X, REN X B, et al. Cyclophilin A (CyPA) induces chemutaxis independent of its peptidylprolyl cis-trans isomerase activity: direct binding between CyPA and the ectodomain of CDlg7 [J]. J Biol Chem, 2011, 286 (10): 8197- 8203.
  • 8SCHLEGEL J, REDZIC J S, PORTER C C, et al. Solution characterization of the extracellular region of CD147 and its interaction with its enzyme ligand eyclophilin A [J]. J Mol Biol, 2009, 391(3): 518-535.
  • 9AKKI A, ZHANG M, MURDOCH C, et al. NADPH oxidase signaling and cardiac myocyte function [J ]. J Mol Cell Cardiol, 2009. 47(1)._ 15-22.
  • 10SATOH K, NIGRO P, ZEIDAN A, et al. Cyclophilin A promotes cardiac hypertrophy in apolipoprotein E-deficient mice [J]. Arterioscler Thromb Vasc Biol, 2011, 31 (5) : 1116- 1123.

同被引文献53

引证文献5

二级引证文献25

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部