成纤维细胞活化蛋白在口腔鳞状细胞癌组织中的表达

本文以各期癌变口腔黏膜为对象,正常和癌前病变口腔黏膜为对照,进行FAP免疫组化染色,并取口腔癌旁组织进行冰冻切片。结果表明,正常和癌前期病变口腔黏膜中,成纤维激活蛋白在的间质成纤维细胞中表达阴性;在口腔鳞状细胞癌间质成纤维细胞中阳性表达,证实了在口腔鳞状细胞癌组织中有FAP的表达且FAP染色分值与OSCC不同病理分级存在正相关关系。

To investigate the expression of F AP in fibroblast of oral carcinoma stroma,cases of OSCC,cases of OLP/OLK and cases of normal oral mocosa were detected for the expressinn of in the stroma by method.The results show that the expression of FAP in OSCC was positive,but in OLP/OLK and in normal oral mocosa it was not detected. There was strong positive correlation between the pathological classification and the number of fibroblasts that expressed FAP.