糖尿病合并下肢动脉性病变的药物治疗

Pharmacological treatment of peripheral arterial disease in patients with diabetes mellitus

糖尿病患者合并下肢动脉病变（PAD）较非糖尿病患者患病率更高、进展速度更快、病变更严重。PAD的内科治疗一方面强调心血管危险因素的全面干预，另一方面是针对间歇性跛行症状的药物治疗，其中己酮可可碱、西洛他唑、沙格雷酯、前列腺素E能改善行走距离，提高生活质量。

Peripheral artery disease （PAD） is more common, severe and more aggravated in the patients with diabetes mellitus. The conservative treatment of PAD should take into consideration two aspects： control of cardiovascular risk factors, and symptomatic treatment of intermitent claudication. Pentoxifylline, cilostazo, Sarpogrelate, and prostaglandins E can alleviate the peripheral ischemic symptoms, increase walking distance and improve the quality of life.