博心通胶囊对脑梗死患者颈动脉不稳定粥样斑块影响的临床观察

Therapeutic Evaluation of Boxintong Capsules on the Unstable Atherosclerotic Plaques of Patients with Cerebral Ischemia

目的:观察博心通胶囊对脑梗死患者颈动脉不稳定粥样斑块的作用。方法:符合纳入标准的脑梗死患者130例随机分为2组,各65例;在常规治疗基础上,对照组口服普罗布考片,博心通组口服博心通胶囊,治疗12个月。分别于治疗前及治疗6、12月,检测患者血脂、颈动脉不稳定粥样硬化斑块的数目、大小以及不良事件情况。结果:治疗6个月后,2组甘油三酯(TG)、总胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)较治疗前均降低(P<0.05),博心通组TG、TC、LDL-C低于对照组(P<0.05);治疗12个月时,2组TG、TC、LDL-C较治疗前均降低(P<0.05),但2组间差异无统计学意义;2组高密度脂蛋白胆固醇(HDL-C)治疗前后水平改变差异无统计学意义;博心通组斑块的"有效"及"稳定"率高于对照组(P<0.05);博心通组治疗有效率及稳定率均显著高于对照组(P<0.01)。2组均无明显不良事件发生。结论:博心通胶囊能有助于降低脑梗死患者血脂、稳定斑块、减少缺血事件发生,且安全。

Objective： To evaluate the therapeutic effects of boxintong capsules on the un- stable atherosclerotic plaques of patients with cerebral ischemia. Methods： One hundred and thirty cerebral ischemia patients with unstable atherosclerotic plaques were enrolled and randomly as- signed to control group （n=65） treated by probucol tablet and boxintong group （n=65） treated by boxintong capsules. The treatment course was 12 months. The serum lipid-TC,TG,HDL-C, LDL-C-and carotid atherosclerotic plaques were measured before and at 6, 12 months after treatment. Adverse events were recorded. Results： Six months after treatment, the levels of TC, TG and LDL-C in both groups were lower than those before treatment （P〈0.05）, and the levels of TC,TG and LDL-C in boxintong group were lower than those of control group （P〈0.05）. Twelve months after treatment, the levels of TC, TG and LDL-C in both groups were lower than those before treatment （P〈0. 05） ,but the levels of TC, TG and LDL-C in the boxintong group were similar with those in the control group. There was no statistical difference before and after the treatment in the level of HDL-C. The efficacy and stability of carotid atherosclerotic plaques in the boxintong group are better than those in the control group （P〈0.05）. The treatment ef- fective rate in the boxintong group was higher than that in the control group （P〈0.05）. No serious adverse events occurred in the both groups. Conclusion： Boxintong capsules were safe and ef fective to treat cerebral ischemia patients with unstable atherosclerotic plaques.