血E_2、P、LH联合阴道B超、尿LH峰监测排卵对IUI手术时机的影响

Effect of ovulation monitoring with blood estradiol,progestogen,and luteinizing hormone combined with transvaginal ultrasonography,urine luteinizing hormone peak on opportunity of intrauterine insemination

目的:分析夫精宫腔内人工授精(Intrauterine insemination,IUI)患者的临床资料,探讨IUI过程中血雌二醇(E2)、孕酮(P)、黄体生成素(LH)联合阴超以及尿LH峰监测排卵对IUI手术时机的影响。方法:选择2009年1月～2011月12月因不孕在广东医学院附属医院生殖医学中心进行IUI治疗的夫妇89对共190个周期,将进入周期的患者随机分为阴道彩超+尿LH峰监测卵泡发育组(A组)和阴道彩超+尿LH峰+血E2、P、LH监测卵泡发育组(B组),比较两组临床妊娠率的差异。结果:B组临床妊娠率高于A组,差异有统计学意义(P<0.05)。结论:IUI过程中血E2、P、LH联合阴超、尿LH峰监测排卵对IUI手术时机的判断优于仅阴超+尿LH峰监测排卵。

Objective： To analyze the clinical data of patients receiving intrauterine insemination （IUI） , explore the effect of ovulation monitoring with blood estradiol, progestogen, and luteinizing hormone （LH） combined with transvaginal ultrasonography, urine LH peak on opportunity of IUI. Methods： A total of 89 couples （ 190 cycles） who received IUI treatment because of infertility in the hospital from January 2009 to December 2011 were selected, and the patients entering into cycles were randomly divided into group A （monitoring follicular development with transvaginal ultrasonography plus urine LH peak） and group B （monitoring follicular development with transvagi- hal uhrasonography plus urine LH peak plus blood estradiol, progestogen, and LH）, the clinical pregnancy rates in the two groups were com- pared. Results ： The clinical pregnancy rate in group B was statistically significantly higher than that in group A （P 〈 0.05） . Conclusion： The value of ovulation monitoring with blood cstradiol, progestogen, and LH combined with transvaginal ultrasonography, urine LH peak during the course of IUI for predicting the opportunity of IUI was superior to that of transvaginal ultrasonography combined with urine LH peak only.