DM2患者微血管病变时测定血浆ET、hs-CRP和TNF-α水平的临床意义

The Clinical Significance of Determining Plasma ET,hs-CRP and TNF-α Levels in Type 2 Diabetes with microvascular Disease

目的:为了探讨2型糖尿病(DM2)患者微血管病变时测定血浆ET、hs-CRP和TNF-α水平的临床意义。方法:ET、hs-CRP和TNF-α测定均采用放射免疫分析,并与65例正常对照组进行了对比性分析。结果:126例DM2患者的血浆ET、hs-CRP和TNF-α水平均非常明显地高于正常对照组(P均<0.01);50例伴有微血管病变的DM2患者血浆ET、hs-CRP和TNF-α水平明显高于不伴有微血管病变的DM2患者(P分别为<0.05、<0.01和<0.01)和非常明显高于正常对照组(P<0.001)。表明:血浆ET、hs-CRP和TNF-α水平随DM2的严重程度而增高。结论:血浆ET、hs-CRP和TNF-α水平是诊断DM2患者或早期发现DM2微血管病变的有效指标。

Objective To explore the clinical significance of determining plasma ET,hs-CRP and TNF-α levels in type 2 diabetes patients with microvascular disease.Methods Plasma ET,hs-CRP and TNF-α levels（with radioimmunoassay,RIA） were determined in 126 patients with type 2 diabetes.126 patients with type 2 diabetes were divided into two groups,one group was composed of 76 type 2 diabetics without microvascular disease,other group was 50 type 2 diabetics with microvascular disease.Compared with 65 normal controls and analysed.Results The levels of plasma ET,hs-CRP and TNF-α in 126 patients with type 2 diabetes were significantly higher than those in normal controls（P all〈0.01）.The levels of plasma ET,hs-CRP and TNF-α in 50 type 2 diabetes patients with microvascular were extremely higher than those in 76 type 2 diabetics patients（P〈0.05,〈0.01and〈0.01,respectively）and dramatically higher than those in 65 normal controls（P all〈0.001）.It indicated the plasma ET,hs-CRP and TNF-α levels were increased with the severity of type 2 diabetics.Conclusion The plasma ET,hs-CRP and TNF-α levels might be helpful indices in diagnosis of type 2 diabeties and to trace type 2 diabetcs patients with microvascular disease earlier.