苍术炮制前后水提物药效学研究

Pharmacodynamics of water extracts from Atractylodes lancea before and after processing

目的:探讨苍术炮制前后水提物药效变化,从药效变化的角度探讨苍术的炮制机制。方法:以湿阻中焦证大鼠为模型,测定不同组别大鼠小肠推进率、血清胃泌素水平、尿量、尿液AQP2含量。结果:各给药组大鼠小肠推进率、血清胃泌素水平增强,麸品较阴性组有显著差异;生品高剂量组能增加模型大鼠尿量、降低尿液AQP2含量,较阴性组有差异。结论:麸品水提物明显增强模型大鼠小肠推进率、提高血清胃泌素水平,提示苍术麸炒以后能增强健脾和胃作用;药物对模型大鼠尿量及尿液AQP2含量的影响,提示苍术麸炒后燥性得以缓和。

Objective： To study the pharmacological changes of Atractylodes lancea before and after processing and the processing mechanism on the basis of the pharmacological changes.Method： The model of dampness retention in the middle-jiao rats was established to determine small intestine peristalsis rate,GAS level,urine volume and AQP2 content from urine in different groups.Result： All treatment groups showed increase in small intestinal peristalsis rate and GAS level.The bran-processed group showed significant difference from the negative group.The high dose A.lancea group showed increase in urine volume and decrease in urine AQP2 content in model rats,which were different from the negative group.Conclusion： Water extracts from bran-processed A.lancea can obviously increase small intestinal peristalsis and GAS level,indicating that A.lancea has the effect for strengthening spleen and stomach after stir-baking with bran.Its impact on urine and urine AQP2 content in model rats demonstrates that its dryness of A.lancea is alleviated after stir-baking with bran.