滇杠柳中的一个新强心苷

A new cardiac glycoside from Periploca forrestii

目的:研究滇杠柳中的化学成分。方法:利用硅胶,RP-18硅胶,MCI,Sephadex LH-20等柱色谱进行分离,波谱分析等方法鉴定化合物结构。结果:从滇杠柳氯仿萃取部分分离鉴定了10个单体化合物:滇杠柳苷元A-3-O-β-洋地黄毒吡喃糖苷(1),β-谷甾醇(2),滇杠柳苷Ⅰ(3),熊果酸(4),杠柳苷元(5),杠柳苷(6),北五加皮苷E(7),periplocoside M(8),胡萝卜苷(9),2α,3α,23-三羟基-乌苏-12-烯-28-羧酸(10)。结论:化合物1为一新的强心苷,化合物8为首次从滇杠柳中分离鉴定。

Objective： To study the chemical constituents of Periploca forrestii.Method： The constituents were separate using such various column chromatographic techniques as silica gel,RP-18 silica gel,MCI and Sephadex LH-20.Their structures were identified by such methods as spectral analysis.Result： Ten compounds were isolated and identified as periforgenin A-3-O-β-digitoxopyranoside（1）,β-sitosterol（2）,periforoside I（3）,ursolic acid（4）,periplogenin（5）,periplocin（6）,glycoside E（7）,periplocoside M（8）,daucosterol（9）,2α,3α,23-trihydroxy-urs-12-en-28-oic acid（10）.Conclusion： Compound 1 was a new cardiac glycoside and compound 8 was reported for the first time from this plant.